Interaction with the Paxillin LD1 Motif Relieves MEKK2 Auto-inhibition
نویسندگان
چکیده
منابع مشابه
Interaction with the Paxillin LD1 Motif Relieves MEKK2 Auto-inhibition
The cell signaling molecule MEK kinase 2 (MEKK2) is a key upstream regulator of MAPK activity that regulates numerous cellular functions, but the mechanisms that control MEKK2 activity are not well understood. Recently, we reported that MEKK2 both binds and promotes ubiquitylation of the scaffold protein paxillin, and thereby modulates the composition of adhesion complexes. In this study, we ha...
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a Seattle Biomedical Research Institute, 4 Nickerson Street, Seattle, WA 98109-1651, USA b Rosetta Inpharmatics, 115th A6e NE, Kirkland, WA 98034, USA c Department of Molecular Microbiology, 760 McDonnell Science Building Box 8230, Washington Uni6ersity School of Medicine, 660 Euclid A6enue, St. Louis, MO 63110-1093, USA d Department of Pathobiology, Uni6ersity of Washington, Seattle, WA 98195,...
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Mitogen-activated protein kinase (MAPK) cascades are central components of the intracellular signaling networks used by eukaryotic cells to respond to a wide spectrum of extracellular stimuli. An MAPK is activated by an MAPK kinase, which in turn is activated by an MAPK kinase kinase (MAP3K). However, little is known about the molecular aspects of the regulation and activation of large numbers ...
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ژورنال
عنوان ژورنال: Journal of Molecular Signaling
سال: 2015
ISSN: 1750-2187
DOI: 10.5334/1750-2187-10-4